[HTML][HTML] Hypoxia activated HGF expression in pancreatic stellate cells confers resistance of pancreatic cancer cells to EGFR inhibition

X Shi, M Wang, Y Zhang, X Guo, M Liu, Z Zhou… - …, 2022 - thelancet.com
… induced the expression and secretion of HGF in PSC via transcription … of pancreatic cancer
cells to EGFR inhibitor in a KRAS-independent manner by activating the PI3K-AKT pathway. …

[HTML][HTML] Targeting HGF/c-MET axis in pancreatic cancer

SP Pothula, Z Xu, D Goldstein, RC Pirola… - International journal of …, 2020 - mdpi.com
… is the hepatocyte growth factor (HGF)/c-MET pathway. HGF … the invasiveness of a pancreatic
cancer cell line (PK8) that … from fibroblast cell line (MRC5) under hypoxic conditions; …

[HTML][HTML] HGF/MET Axis induces tumor secretion of tenascin-C and promotes stromal rewiring in pancreatic cancer

C Modica, M Olivero, F Zuppini, M Milan, C Basilico… - Cancers, 2021 - mdpi.com
… receptor by its ligand, the hepatocyte growth factor (HGF), … pair sustains the interaction
between cancer cells and the … acts as a pro-invasive factor on pancreatic cancer cells, little is …

Paracrine HGF promotes EMT and mediates the effects of PSC on chemoresistance by activating c-Met/PI3K/Akt signaling in pancreatic cancer in vitro

J Xu, S Liu, X Yang, S Cao, Y Zhou - Life Sciences, 2020 - Elsevier
… (PC) by secreting hepatocyte growth factor (HGF). The … modulate proliferation, invasion
and migration of cancer cells [24,25]… hypoxia, which becomes a self-perpetuating hypoxia-fibrosis …

[HTML][HTML] Crosstalk between tumor and stromal cells in pancreatic ductal adenocarcinoma

N Sperb, M Tsesmelis, T Wirth - International journal of molecular …, 2020 - mdpi.com
into myofibroblasts through the accumulation of the hypoxia-… and invasiveness of primary
pancreatic cancer stem cells. In … -1, and hepatocyte growth factor (HGF), which increase the …

[HTML][HTML] Curcumin inhibits pancreatic cancer cell invasion and EMT by interfering with tumorstromal crosstalk under hypoxic conditions via the IL‑6/ERK/NF‑κB axis

W Li, L Sun, J Lei, Z Wu, Q Ma… - Oncology …, 2020 - spandidos-publications.com
… affect pancreatic cancer cell invasion and EMT by interfering with tumorstromal interaction
under hypoxic … the hepatocyte growth factor (HGF)/c-Met/survivin pathway, which is negatively …

Pancreatic stellate cells: Aiding and abetting pancreatic cancer progression

SP Pothula, RC Pirola, JS Wilson, MV Apte - Pancreatology, 2020 - Elsevier
… of organotypic pancreatic tissue cultured under hypoxic … facilitate the invasion and co-migration
of cancer cells through the … PSCs secrete the precursor form of hepatocyte growth factor (…

Signaling pathways involved in pancreatic stellate cells activity and interaction with pancreatic cancer cells

NV Stanishevska - Morphologia= Морфологія, 2021 - repo.dma.dp.ua
… hepatoma growth factor gene) under hypoxic conditions under the … invasion through the
hepatocyte growth factor /c-Met/survivin … pathways disrupts tumor-stromal crosstalk and improves

[HTML][HTML] HGF/c-MET inhibition as adjuvant therapy improves outcomes in an orthotopic mouse model of pancreatic cancer

TCY Pang, Z Xu, AR Mekapogu, S Pothula, T Becker… - Cancers, 2021 - mdpi.com
… of hepatocyte growth factor (HGF) and c-MET when used as … of hepatocyte growth factor
(HGF)/c-MET pathway, a major mediator of pancreatic stellate cell (PSC)−PC cell interactions, …

[HTML][HTML] Role of c-MET inhibitors in overcoming drug resistance in spheroid models of primary human pancreatic cancer and stellate cells

O Firuzi, PP Che, B El Hassouni, M Buijs, S Coppola… - Cancers, 2019 - mdpi.com
… have a crucial impact on invasion of PDAC cells [18], create … shows the paracrine source of
hepatocyte growth factor (HGF) … there is a reciprocal interaction between PDAC cells and an …